Inflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology

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MRI was available in five controls. While MRI was normal, FOI showed minimal changes in CI and P2 (1 out of 60 joints, 1.2%, and 2 out of 60 joints, 3.3%) and none in P1 and P3. CE and laboratory tests (erythrocyte sedimentation rate (ESR) and C reactive protein (CRP)) were performed. Clinical swollen and tender joints (including distal interphalangeal joint (DIP)) were scored for presence and absence (0-1). The Disease Activity Score 28 (DAS28)18 was used to assess disease activity in patients with RA, psoriatic arthritis (PsA) and undifferentiated arthritis (uA).

FOI showed a higher rate of positive findings than the other compared modalities. In an FOI sequence, three phases could be distinguished, with different sensitivity and specificity as well with different AR. FOI scores correlated significantly with assessment of disease activity (DAS28, US score, RAMRIS). In healthy subjects, FOI was negative in almost all joints. In 12 controls (6 healthy and 6 with arthralgia without any sign of inflammatory rheumatic disease; median age 30 years, range 21-56 years, 3 women), 360 joints were evaluated.

FOI agreed well with clinically swollen and tender joints. Disagreement of FOI and CE mainly resulted from the higher rate of positive findings in FOI. The highest agreement was seen for FOI P1 and swollen and tender joints, indicating that P1 displays joints with high clinical activity.

Even individuals without evidence of GERD may experience some mild symptoms that are commonly ascribed to GERD. GERD symptom thresholds derived in this study can be used to define the global symptom relief in patients with GERD. Subjects included 488 consecutive adults (mean age, 56.1 ± 8.9 years) who underwent transoral EGD for gastric cancer screening between February 2010 and March 2011. All procedures were performed by an endoscopist with 15 years of experience. Based on a questionnaire survey using the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), symptoms (dyspepsia and acid reflux symptoms) and the number of vomiting reflexes during EGD were recorded.

Indocyanine green-enhanced imaging of antigen-induced arthritis with an integrated optical imaging/radiography system.

After the Phase I study period of 8 weeks, treatment intervals could be prolonged in responding patients. DLT was defined according to CTC. Critical parameters were grade 3 toxicity for hematological parameters; coagulation parameters; stomatitis; diarrhea; gastritis; gastrointestinal tract ulcers; mucositis; diseases of the lung, kidneys, urinary tract, skin, eyes, and ears; and neurological or autoimmune disorders. CTC grade 4 toxicity was chosen for hepatic function, metabolic disorders, vascular diseases, loss of appetite, and alopecia. Toxicity for each patient was assessed every week.

An interview-based rating scale consisting of 15 items for assessment of gastrointestinal symptoms in irritable bowel syndrome and peptic ulcer disease has been developed. The interrater reliability was estimated by means of independent and simultaneous duplicate ratings by two raters in 20 cases and ranged from 0.86 to 1.00.

To objectively determine the success of therapy in GERD, multisymptom GERD questionnaires have been developed. The most promising are those that reflect the numerous types of GERD symptoms, are patient-administered, quantitative, responsive, and have been validated in both NERD and erosive GERD patients. The ReQuest instrument is especially attractive as it records the entire range of GERD symptoms on a daily basis (including also their frequency and intensity) and is responsive to changes with time and with therapy.

Unfortunately, up to 90% of patients with ductopenic rejection in first graft have experienced recurrent ductopenic rejection after retransplantation [36]. Clinical symptoms in chronic rejection are usually caused by damage to small bile ducts. Therefore, interventional approaches are rarely effective and not advisable.

MRI is considered the gold standard for imaging of synovitis, and MRI bone marrow oedema has been shown to be the strongest independent predictor of radiographic progression in RA.6 7 However, broader usage of MRI in clinical routine settings may be restricted by workflow considerations, cost and limited availability. MTX-HSA every 2-4 weeks, achieving plasma concentrations between 10 and 20 μmol/liter, proved to be safe and effective, based on observation of the three responding patients. All 17 patients were evaluable for DLT within the first two consecutive courses; 13 patients received at least three courses, 12 patients received at least seven courses, and 8 patients received more than seven consecutive courses. One patient withdrew informed consent after two courses, and treatment was discontinued in two patients because of tumor-induced health deterioration after the second or third injection. Indocyanine green (ICG)-enhanced fluorescence optical imaging (FOI) is an established technology for imaging of inflammation in animal models.

gerd bahner
gerd bahner

Severe gastroesophageal reflux disease (GERD) is a lifelong problem that can be complicated by peptic esophageal stricture and adenocarcinoma of the esophagus. This was a post hoc analysis of a multicenter prospective cohort study. A total of 5,279 GERD patients with Frequency Scale for the Symptoms of GERD (FSSG) scores ≥ 8 points at baseline were analyzed. Correlations between HRQOL and FSSG were investigated and logistic regression analysis was performed. The pathogenesis of chronic rejection still remains uncertain.

CT scans showed a reduction of the pulmonary metastases and the intra-abdominal lymphomas of more than 80%. Until September 1998, 39 courses of MTX-HSA had been administered (cumulative MTX dose, 3430 mg; 123 mg MTX/month).

Evaluation of the GSRS and UESS with regard to internal consistency, construct validity, and the ability to detect changes showed them to be satisfactory. The psychometric documentation of the measures indicates that they may give reliable and clinically valid information when used for evaluation of medical treatments in upper gastrointestinal disease. Further documentation of the methods is, however, needed to establish a generally acceptable QoL assessment in gastroenterology. Many questionnaires that assess subjective symptoms or health-related quality of life (HRQOL) have been developed to confirm the efficacy of treatment in patients with gastroesophageal reflux disease (GERD). However, few reports have correlated early improvements in scale scores with predictions of subsequent therapeutic responses.

gerd bahner

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